The potentiation of warfarin anticoagulation by amiodarone.
نویسندگان
چکیده
The potentiation of the anticoagulant effect of sodium warfarin by amiodarone is reported in 10 patients. Amiodarone appears to augment the depression of vitamin K-dependent coagulation factors caused by warfarin by an uncertain mechanism, and may lead to serious bleeding. The maintenance dose of warfarin should be halved when amiodarone and warfarin are prescribed together.
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عنوان ژورنال:
- Circulation
دوره 65 5 شماره
صفحات -
تاریخ انتشار 1982